What is the difference between De novo and salvage pathway of nucleotide synthesis?

In: Human Anatomy

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Difference between De Novo and Salvage

In De Novo pathways, the nucleotide bases are assembled from simpler compounds. The framework for a pyrimidine (= thymine and cytosine or uracil) base is assembled first and then attached to ribose. The framework for a purine (= adenine and guanine) base is synthesized piece by piece directly onto a ribose-based structure. In salvage pathways, performed bases are recovered and reconnected to a ribose unit.
To put it even simpler; in De Novo pathways, the bases of the nucleotides are made from scratch by using simpler starting materials (including amino acids). For this process, ATP hydrolysis is required. Salvage pathways recycle already used bases by reattaching them to a ribose.

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